4HNP
Crystal structure of yeast 20S proteasome in complex with vinylketone carmaphycin analogue VNK1
Summary for 4HNP
Entry DOI | 10.2210/pdb4hnp/pdb |
Related | 4HRC 4HRD |
Related PRD ID | PRD_000902 PRD_000904 |
Descriptor | Proteasome component Y7, Proteasome component C11, Proteasome component PRE2, ... (17 entities in total) |
Functional Keywords | proteasome, inhibitor, carmaphycin, epoxyketone, vinylketone, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Saccharomyces cerevisiae S288c (Baker's yeast) More |
Cellular location | Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 |
Total number of polymer chains | 28 |
Total formula weight | 707278.56 |
Authors | Trivella, D.B.B.,Stein, M.,Groll, M. (deposition date: 2012-10-20, release date: 2014-01-29, Last modification date: 2014-07-02) |
Primary citation | Trivella, D.B.,Pereira, A.R.,Stein, M.L.,Kasai, Y.,Byrum, T.,Valeriote, F.A.,Tantillo, D.J.,Groll, M.,Gerwick, W.H.,Moore, B.S. Enzyme inhibition by hydroamination: design and mechanism of a hybrid carmaphycin-syringolin enone proteasome inhibitor. Chem.Biol., 21:782-791, 2014 Cited by PubMed: 24930969DOI: 10.1016/j.chembiol.2014.04.010 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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