4HLZ

Crystal Structure of Fab C179 in Complex with a H2N2 influenza virus hemagglutinin

4HLZ の概要

• エントリーDOI: 10.2210/pdb4hlz/pdb
• 分子名称: Hemagglutinin HA1, 1,2-ETHANEDIOL, Hemagglutinin HA2, ... (10 entities in total)
• 機能のキーワード: neutralizing antibodies, antibody affinity, antigens, epitopes, glycosylation, hemagglutinin glycoproteins, immunoglobulin fab fragments, h2n2 subtype, influenza vaccines, avian flu, envelope protein, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Influenza A virus; 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 319542.85

構造登録者

Dreyfus, C.,Wilson, I.A. (登録日: 2012-10-17, 公開日: 2013-04-17, 最終更新日: 2024-11-06)

主引用文献

Dreyfus, C.,Ekiert, D.C.,Wilson, I.A.
Structure of a classical broadly neutralizing stem antibody in complex with a pandemic h2 influenza virus hemagglutinin.
J.Virol., 87:7149-7154, 2013

PubMed Abstract: We report the structural characterization of the first antibody identified to cross-neutralize multiple subtypes of influenza A viruses. The crystal structure of mouse antibody C179 bound to the pandemic 1957 H2N2 hemagglutinin (HA) reveals that it targets an epitope on the HA stem similar to those targeted by the recently identified human broadly neutralizing antibodies. C179 also inhibits the low-pH conformational change of the HA but uses a different angle of approach and both heavy and light chains.

PubMed: 23552413
DOI: 10.1128/JVI.02975-12

実験手法

X-RAY DIFFRACTION (2.9 Å)