4HKR
Calcium release-activated calcium (CRAC) channel ORAI
Summary for 4HKR
| Entry DOI | 10.2210/pdb4hkr/pdb |
| Descriptor | Calcium release-activated calcium channel protein 1, BARIUM ION, ZINC ION, ... (4 entities in total) |
| Functional Keywords | calcium channel, orai1, eukaryotic membrane protein, membrane protein, ion channel, stim, membrane, transport protein |
| Biological source | Drosophila melanogaster (Fruit fly) |
| Cellular location | Cell membrane; Multi-pass membrane protein (By similarity): Q9U6B8 |
| Total number of polymer chains | 2 |
| Total formula weight | 49009.22 |
| Authors | Long, S.B.,Hou, X. (deposition date: 2012-10-15, release date: 2012-11-28, Last modification date: 2023-09-20) |
| Primary citation | Hou, X.,Pedi, L.,Diver, M.M.,Long, S.B. Crystal structure of the calcium release-activated calcium channel Orai. Science, 338:1308-1313, 2012 Cited by PubMed Abstract: The plasma membrane protein Orai forms the pore of the calcium release-activated calcium (CRAC) channel and generates sustained cytosolic calcium signals when triggered by depletion of calcium from the endoplasmic reticulum. The crystal structure of Orai from Drosophila melanogaster, determined at 3.35 angstrom resolution, reveals that the calcium channel is composed of a hexameric assembly of Orai subunits arranged around a central ion pore. The pore traverses the membrane and extends into the cytosol. A ring of glutamate residues on its extracellular side forms the selectivity filter. A basic region near the intracellular side can bind anions that may stabilize the closed state. The architecture of the channel differs markedly from other ion channels and gives insight into the principles of selective calcium permeation and gating. PubMed: 23180775DOI: 10.1126/science.1228757 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.3511 Å) |
Structure validation
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