Crystal structure of p53 core domain in complex with DNA

Summary for 4HJE

DescriptorCellular tumor antigen p53, DNA (5'-D(*TP*CP*AP*CP*AP*AP*GP*TP*TP*AP*GP*AP*GP*AP*CP*AP*AP*GP*CP*CP*T)-3'), DNA (5'-D(*AP*GP*GP*CP*TP*TP*GP*TP*CP*TP*CP*TP*AP*AP*CP*TP*TP*GP*TP*GP*A)-3'), ... (5 entities in total)
Functional Keywordstumor suppressor, transcription-dna complex, transcription/dna
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm P04637
Total number of polymer chains6
Total molecular weight103264.5
Chen, Y.,Chen, L. (deposition date: 2012-10-12, release date: 2013-07-17, Last modification date: 2013-10-09)
Primary citation
Chen, Y.,Zhang, X.,Dantas Machado, A.C.,Ding, Y.,Chen, Z.,Qin, P.Z.,Rohs, R.,Chen, L.
Structure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertion.
Nucleic Acids Res., 41:8368-8376, 2013
PubMed: 23836939 (PDB entries with the same primary citation)
DOI: 10.1093/nar/gkt584
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers70.1%3.1%9.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution