4HJE

Crystal structure of p53 core domain in complex with DNA

Summary for 4HJE

• Entry DOI: 10.2210/pdb4hje/pdb
• Descriptor: Cellular tumor antigen p53, DNA (5'-D(*TP*CP*AP*CP*AP*AP*GP*TP*TP*AP*GP*AP*GP*AP*CP*AP*AP*GP*CP*CP*T)-3'), DNA (5'-D(*AP*GP*GP*CP*TP*TP*GP*TP*CP*TP*CP*TP*AP*AP*CP*TP*TP*GP*TP*GP*A)-3'), ... (5 entities in total)
• Functional Keywords: tumor suppressor, transcription-dna complex, transcription/dna
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
• Total number of polymer chains: 6
• Total formula weight: 103264.50

Authors

Chen, Y.,Chen, L. (deposition date: 2012-10-12, release date: 2013-07-17, Last modification date: 2024-02-28)

• Primary citation: Chen, Y.,Zhang, X.,Dantas Machado, A.C.,Ding, Y.,Chen, Z.,Qin, P.Z.,Rohs, R.,Chen, L.; Structure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertion.; Nucleic Acids Res., 41:8368-8376, 2013; PubMed: 23836939; DOI: 10.1093/nar/gkt584

Experimental method

X-RAY DIFFRACTION (1.907 Å)