4HJE

Crystal structure of p53 core domain in complex with DNA

4HJE の概要

• エントリーDOI: 10.2210/pdb4hje/pdb
• 分子名称: Cellular tumor antigen p53, DNA (5'-D(*TP*CP*AP*CP*AP*AP*GP*TP*TP*AP*GP*AP*GP*AP*CP*AP*AP*GP*CP*CP*T)-3'), DNA (5'-D(*AP*GP*GP*CP*TP*TP*GP*TP*CP*TP*CP*TP*AP*AP*CP*TP*TP*GP*TP*GP*A)-3'), ... (5 entities in total)
• 機能のキーワード: tumor suppressor, transcription-dna complex, transcription/dna
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 103264.50

構造登録者

Chen, Y.,Chen, L. (登録日: 2012-10-12, 公開日: 2013-07-17, 最終更新日: 2024-02-28)

• 主引用文献: Chen, Y.,Zhang, X.,Dantas Machado, A.C.,Ding, Y.,Chen, Z.,Qin, P.Z.,Rohs, R.,Chen, L.; Structure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertion.; Nucleic Acids Res., 41:8368-8376, 2013; PubMed: 23836939; DOI: 10.1093/nar/gkt584

実験手法

X-RAY DIFFRACTION (1.907 Å)