4HIQ
The Structure of V122I Mutant Transthyretin in Complex with AG10
Summary for 4HIQ
Entry DOI | 10.2210/pdb4hiq/pdb |
Related | 3TCT 4HIS |
Descriptor | Transthyretin, 3-[3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy]-4-fluorobenzoic acid (3 entities in total) |
Functional Keywords | thyroid hormone transport, thyroxine, retinol binding protein, hormone binding protein-inhibitor complex, hormone binding protein/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P02766 |
Total number of polymer chains | 2 |
Total formula weight | 28167.38 |
Authors | Connelly, S.,Alhamadsheh, M.,Graef, I.,Wilson, I.A. (deposition date: 2012-10-11, release date: 2013-06-05, Last modification date: 2023-09-20) |
Primary citation | Penchala, S.C.,Connelly, S.,Wang, Y.,Park, M.S.,Zhao, L.,Baranczak, A.,Rappley, I.,Vogel, H.,Liedtke, M.,Witteles, R.M.,Powers, E.T.,Reixach, N.,Chan, W.K.,Wilson, I.A.,Kelly, J.W.,Graef, I.A.,Alhamadsheh, M.M. AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin. Proc.Natl.Acad.Sci.USA, 110:9992-9997, 2013 Cited by PubMed: 23716704DOI: 10.1073/pnas.1300761110 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.18 Å) |
Structure validation
Download full validation report