4HEW
Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure
Summary for 4HEW
| Entry DOI | 10.2210/pdb4hew/pdb |
| Related | 4HEY 4HEZ 4HF3 |
| Descriptor | Carbonic anhydrase 2, ZINC ION, 2-METHYLIMIDAZOLE, ... (4 entities in total) |
| Functional Keywords | hydration/dehydration, his64ala, lyase |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: P00918 |
| Total number of polymer chains | 1 |
| Total formula weight | 29451.61 |
| Authors | Aggarwal, M.,McKenna, R. (deposition date: 2012-10-04, release date: 2013-10-23, Last modification date: 2023-09-20) |
| Primary citation | Aggarwal, M.,Kondeti, B.,Tu, C.,Maupin, C.M.,Silverman, D.N.,McKenna, R. Structural insight into activity enhancement and inhibition of H64A carbonic anhydrase II by imidazoles. IUCrJ, 1:129-135, 2014 Cited by PubMed: 25075329DOI: 10.1107/S2052252514004096 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.6984 Å) |
Structure validation
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