4HEV

Clostridium Botulinum Serotype A Light Chain Inhibited By Adamantane Hydroxamate

4HEV の概要

• エントリーDOI: 10.2210/pdb4hev/pdb
• 分子名称: Botulinum neurotoxin type A light chain, ZINC ION, N-hydroxy-2-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]acetamide, ... (4 entities in total)
• 機能のキーワード: zn2+-dependent metalloprotease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Clostridium botulinum
• 細胞内の位置: Botulinum neurotoxin A light chain: Secreted. Botulinum neurotoxin A heavy chain: Secreted: P10845
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 101753.48

構造登録者

Silvaggi, N.R.,Allen, K.N. (登録日: 2012-10-04, 公開日: 2013-01-23, 最終更新日: 2023-09-20)

• 主引用文献: Silhar, P.,Silvaggi, N.R.,Pellett, S.,Johnson, E.A.,Allen, K.N.,Janda, K.D.; Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: synthesis, crystallography, modeling, kinetic and cellular based studies.; Bioorg.Med.Chem., 21:1344-1348, 2013; PubMed: 23340139; DOI: 10.1016/j.bmc.2012.12.001

実験手法

X-RAY DIFFRACTION (2.5 Å)