4HDB
Crystal Structure of HIV-1 protease mutants D30N complexed with inhibitor GRL-0519
Summary for 4HDB
Entry DOI | 10.2210/pdb4hdb/pdb |
Related | 3OK9 4HDF 4HDP 4HE9 4HEG |
Descriptor | HIV-1 Protease, (3R,3aS,3bR,6aS,7aS)-octahydrodifuro[2,3-b:3',2'-d]furan-3-yl [(1S,2R)-1-benzyl-2-hydroxy-3-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}propyl]carbamate, SODIUM ION, ... (5 entities in total) |
Functional Keywords | aspartic acid protease, drug resistance, hiv-1 protease inhibitor grl-0519, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus type 1 (HIV-1) |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367 |
Total number of polymer chains | 2 |
Total formula weight | 22177.99 |
Authors | Zhang, H.,Wang, Y.-F.,Shen, C.H.,Agniswamy, J.,Weber, I.T. (deposition date: 2012-10-02, release date: 2013-08-14, Last modification date: 2023-09-20) |
Primary citation | Zhang, H.,Wang, Y.F.,Shen, C.H.,Agniswamy, J.,Rao, K.V.,Xu, C.X.,Ghosh, A.K.,Harrison, R.W.,Weber, I.T. Novel P2 tris-tetrahydrofuran group in antiviral compound 1 (GRL-0519) fills the S2 binding pocket of selected mutants of HIV-1 protease. J.Med.Chem., 56:1074-1083, 2013 Cited by PubMed: 23298236DOI: 10.1021/jm301519z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.49 Å) |
Structure validation
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