4HBK

Structure of the Aldose Reductase from Schistosoma japonicum

Summary for 4HBK

• Entry DOI: 10.2210/pdb4hbk/pdb
• Descriptor: Aldo-keto reductase family 1, member B4 (Aldose reductase) (2 entities in total)
• Functional Keywords: aldose reductase, oxidoreductase
• Biological source: Schistosoma japonicum (Blood fluke)
• Total number of polymer chains: 1
• Total formula weight: 39235.89

Authors

Liu, J.,Cheng, J.,Zhang, X.,Yang, Z.,Hu, W.,Xu, Y. (deposition date: 2012-09-28, release date: 2013-06-26, Last modification date: 2023-09-20)

Primary citation

Liu, J.,Dyer, D.,Cheng, J.,Wang, J.,Wang, S.,Yang, Z.,Wang, X.,Hu, W.
Aldose reductase from Schistosoma japonicum: crystallization and structure-based inhibitor screening for discovering antischistosomal lead compounds.
Parasit Vectors, 6:162-162, 2013

PubMed Abstract: Schistosomiasis is a neglected tropical disease with high morbidity and mortality in the world. Currently, the treatment of this disease depends almost exclusively on praziquantel (PZQ); however, the emergence of drug resistance to PZQ in schistosomes makes the development of novel drugs an urgent task. Aldose reductase (AR), an important component that may be involved in the schistosome antioxidant defense system, is predicted as a potential drug target.

PubMed: 23734964
DOI: 10.1186/1756-3305-6-162

Experimental method

X-RAY DIFFRACTION (2.2 Å)