4HBK

Structure of the Aldose Reductase from Schistosoma japonicum

4HBK の概要

• エントリーDOI: 10.2210/pdb4hbk/pdb
• 分子名称: Aldo-keto reductase family 1, member B4 (Aldose reductase) (2 entities in total)
• 機能のキーワード: aldose reductase, oxidoreductase
• 由来する生物種: Schistosoma japonicum (Blood fluke)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39235.89

構造登録者

Liu, J.,Cheng, J.,Zhang, X.,Yang, Z.,Hu, W.,Xu, Y. (登録日: 2012-09-28, 公開日: 2013-06-26, 最終更新日: 2023-09-20)

主引用文献

Liu, J.,Dyer, D.,Cheng, J.,Wang, J.,Wang, S.,Yang, Z.,Wang, X.,Hu, W.
Aldose reductase from Schistosoma japonicum: crystallization and structure-based inhibitor screening for discovering antischistosomal lead compounds.
Parasit Vectors, 6:162-162, 2013

PubMed Abstract: Schistosomiasis is a neglected tropical disease with high morbidity and mortality in the world. Currently, the treatment of this disease depends almost exclusively on praziquantel (PZQ); however, the emergence of drug resistance to PZQ in schistosomes makes the development of novel drugs an urgent task. Aldose reductase (AR), an important component that may be involved in the schistosome antioxidant defense system, is predicted as a potential drug target.

PubMed: 23734964
DOI: 10.1186/1756-3305-6-162

実験手法

X-RAY DIFFRACTION (2.2 Å)