4H97
Candida albicans dihydrofolate reductase complexed with NADPH and 5-{3-[3-methoxy-5-(4-methylphenyl)phenyl]but-1-yn-1-yl}-6-methylpyrimidine-2,4-diamine (UCP111D4M)
4H97 の概要
エントリーDOI | 10.2210/pdb4h97/pdb |
関連するPDBエントリー | 3QLR 3QLS 3QLW 3QLX 3QLY 3QLZ 4H95 4H96 4H98 |
分子名称 | Dihydrofolate Reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[(3R)-3-(5-methoxy-4'-methylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine, ... (5 entities in total) |
機能のキーワード | antifungal agents, candida albicans, drug design, enzyme inhibitors, fungal proteins, tetrahydrofolate dehydrogenase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
由来する生物種 | Candida albicans |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 46228.21 |
構造登録者 | |
主引用文献 | Paulsen, J.L.,Viswanathan, K.,Wright, D.L.,Anderson, A.C. Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among species. Bioorg.Med.Chem.Lett., 23:1279-1284, 2013 Cited by PubMed: 23375226DOI: 10.1016/j.bmcl.2013.01.008 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.2 Å) |
構造検証レポート
検証レポート(詳細版)
をダウンロード
![ダウンロード](/newweb/media/icons/dl.png)