4H85

Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/(R)-alpha-chloroisocaproate complex with ADP

4H85 の概要

• エントリーDOI: 10.2210/pdb4h85/pdb
• 関連するPDBエントリー: 3TZ4 3TZ5 4DZY 4E00 4H7Q 4H81
• 分子名称: [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (6 entities in total)
• 機能のキーワード: ghkl protein kinase, allosteric kinase inhibitor, branched-chain alpha-ketoacid, branched-chain amino acids, maple syrup urine disease, diabetes and obesity, bergerat nucleotide-binding fold, protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Rattus norvegicus (rat)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 48015.45

構造登録者

Tso, S.C.,Chuang, J.L.,Gui, W.J.,Wynn, R.M.,Li, J.,Chuang, D.T. (登録日: 2012-09-21, 公開日: 2013-06-05, 最終更新日: 2024-02-28)

• 主引用文献: Tso, S.C.,Qi, X.,Gui, W.J.,Chuang, J.L.,Morlock, L.K.,Wallace, A.L.,Ahmed, K.,Laxman, S.,Campeau, P.M.,Lee, B.H.,Hutson, S.M.,Tu, B.P.,Williams, N.S.,Tambar, U.K.,Wynn, R.M.,Chuang, D.T.; Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase.; Proc.Natl.Acad.Sci.USA, 110:9728-9733, 2013; PubMed: 23716694; DOI: 10.1073/pnas.1303220110

実験手法

X-RAY DIFFRACTION (2.1 Å)