4H7Q

Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase in complex with alpha-ketoisocaproic acid and ADP

Summary for 4H7Q

Entry DOI	10.2210/pdb4h7q/pdb
Related	3TZ4 3TZ5 4DZY 4E00
Descriptor	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial, ADENOSINE-5'-DIPHOSPHATE, 2-OXO-4-METHYLPENTANOIC ACID, ... (6 entities in total)
Functional Keywords	ghkl protein kinase, allosteric kinase inhibitor, branched-chain alpha-ketoacid, branched-chain amino acids, maple syrup urine disease, diabetes and obesity, bergerat nucleotide-binding fold, protein kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Rattus norvegicus (rat)
Total number of polymer chains	1
Total formula weight	47994.99
Authors	Tso, S.C.,Chuang, J.L.,Gui, W.J.,Wynn, R.M.,Li, J.,Chuang, D.T. (deposition date: 2012-09-20, release date: 2013-06-05, Last modification date: 2024-02-28)
Primary citation	Tso, S.C.,Qi, X.,Gui, W.J.,Chuang, J.L.,Morlock, L.K.,Wallace, A.L.,Ahmed, K.,Laxman, S.,Campeau, P.M.,Lee, B.H.,Hutson, S.M.,Tu, B.P.,Williams, N.S.,Tambar, U.K.,Wynn, R.M.,Chuang, D.T. Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase. Proc.Natl.Acad.Sci.USA, 110:9728-9733, 2013 Cited by PubMed: 23716694 DOI: 10.1073/pnas.1303220110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation