4H7Q
Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase in complex with alpha-ketoisocaproic acid and ADP
4H7Q の概要
エントリーDOI | 10.2210/pdb4h7q/pdb |
関連するPDBエントリー | 3TZ4 3TZ5 4DZY 4E00 |
分子名称 | [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial, ADENOSINE-5'-DIPHOSPHATE, 2-OXO-4-METHYLPENTANOIC ACID, ... (6 entities in total) |
機能のキーワード | ghkl protein kinase, allosteric kinase inhibitor, branched-chain alpha-ketoacid, branched-chain amino acids, maple syrup urine disease, diabetes and obesity, bergerat nucleotide-binding fold, protein kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Rattus norvegicus (rat) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 47994.99 |
構造登録者 | Tso, S.C.,Chuang, J.L.,Gui, W.J.,Wynn, R.M.,Li, J.,Chuang, D.T. (登録日: 2012-09-20, 公開日: 2013-06-05, 最終更新日: 2024-02-28) |
主引用文献 | Tso, S.C.,Qi, X.,Gui, W.J.,Chuang, J.L.,Morlock, L.K.,Wallace, A.L.,Ahmed, K.,Laxman, S.,Campeau, P.M.,Lee, B.H.,Hutson, S.M.,Tu, B.P.,Williams, N.S.,Tambar, U.K.,Wynn, R.M.,Chuang, D.T. Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase. Proc.Natl.Acad.Sci.USA, 110:9728-9733, 2013 Cited by PubMed: 23716694DOI: 10.1073/pnas.1303220110 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.1 Å) |
構造検証レポート
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