4H6O
Sterol 14-alpha demethylase (CYP51)from Trypanosoma cruzi in complex with the inhibitor NEU321 (1-(3-(4-chloro-3,5-dimethylphenoxy)benzyl)-1H-imidazole
Summary for 4H6O
Entry DOI | 10.2210/pdb4h6o/pdb |
Related | 3k1o 3ksw |
Descriptor | Sterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, 1-[3-(4-chloro-3,5-dimethylphenoxy)benzyl]-1H-imidazole, ... (4 entities in total) |
Functional Keywords | sterol 14-alpha demethylase (cyp51), cytochrome p450, heme, oxidoreductase, monooxygenase, sterol biosynthesis, eukaryotic membranes, cytochrome p450 fold, endoplasmic reticulum membrane, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Trypanosoma cruzi |
Cellular location | Membrane ; Single-pass membrane protein : Q7Z1V1 |
Total number of polymer chains | 1 |
Total formula weight | 53613.38 |
Authors | Wawrzak, Z.,Hargrove, T.Y.,Pollastri, M.P.,Lepesheva, G.I. (deposition date: 2012-09-19, release date: 2013-03-20, Last modification date: 2023-09-20) |
Primary citation | Andriani, G.,Amata, E.,Beatty, J.,Clements, Z.,Coffey, B.J.,Courtemanche, G.,Devine, W.,Erath, J.,Juda, C.E.,Wawrzak, Z.,Wood, J.T.,Lepesheva, G.I.,Rodriguez, A.,Pollastri, M.P. Antitrypanosomal Lead Discovery: Identification of a Ligand-Efficient Inhibitor of Trypanosoma cruzi CYP51 and Parasite Growth. J.Med.Chem., 56:2556-2567, 2013 Cited by PubMed: 23448316DOI: 10.1021/jm400012e PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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