4H6J
Identification of Cys 255 in HIF-1 as a novel site for development of covalent inhibitors of HIF-1 /ARNT PasB domain protein-protein interaction.
Summary for 4H6J
Entry DOI | 10.2210/pdb4h6j/pdb |
Related | 3F1P |
Descriptor | HYPOXIA INDUCIBLE FACTOR 1-ALPHA, ARYL HYDROCARBON NUCLEAR TRANSLOCATOR (3 entities in total) |
Functional Keywords | pas domain, heterodimer, hypoxia inducible factor, transcription factor, arnt, transcription |
Biological source | Homo sapiens More |
Cellular location | Cytoplasm : Q16665 Nucleus: P27540 |
Total number of polymer chains | 2 |
Total formula weight | 26692.05 |
Authors | Cardoso, R.,Love, R.A.,Nilsson, C.,Bergqvist, S.,Nowlin, D.,Yan, J.,Liu, K.,Zhu, J.,Chen, P.,Deng, Y.-L.,Dyson, H.J.,Greig, M.J.,Brooun, A. (deposition date: 2012-09-19, release date: 2012-12-05, Last modification date: 2024-02-28) |
Primary citation | Cardoso, R.,Love, R.,Nilsson, C.L.,Bergqvist, S.,Nowlin, D.,Yan, J.,Liu, K.K.,Zhu, J.,Chen, P.,Deng, Y.L.,Dyson, H.J.,Greig, M.J.,Brooun, A. Identification of Cys255 in HIF-1 alpha as a novel site for development of covalent inhibitors of HIF-1 alpha /ARNT PasB domain protein-protein interaction. Protein Sci., 21:1885-1896, 2012 Cited by PubMed: 23033253DOI: 10.1002/pro.2172 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.52 Å) |
Structure validation
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