4H5E

Crystal structure of human FPPS in ternary complex with YS0470 and isopentenyl pyrophosphate

Summary for 4H5E

Entry DOI	10.2210/pdb4h5e/pdb
Related	4DEM 4H5C 4H5D
Descriptor	Farnesyl pyrophosphate synthase, [({4-[4-(propan-2-yloxy)phenyl]pyridin-2-yl}amino)methanediyl]bis(phosphonic acid), ISOPENTYL PYROPHOSPHATE, ... (5 entities in total)
Functional Keywords	transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P14324
Total number of polymer chains	1
Total formula weight	43868.28
Authors	Park, J.,Lin, Y.-S.,Tsantrizos, Y.S.,Berghuis, A.M. (deposition date: 2012-09-18, release date: 2012-12-26, Last modification date: 2023-09-20)
Primary citation	Park, J.,Lin, Y.S.,De Schutter, J.W.,Tsantrizos, Y.S.,Berghuis, A.M. Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme's active site closure. Bmc Struct.Biol., 12:32-32, 2012 Cited by PubMed: 23234314 DOI: 10.1186/1472-6807-12-32 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.04 Å)

Structure validation