4H5D

Crystal structure of human FPPS in ternary complex with YS0470 and inorganic pyrophosphate

4H5D の概要

• エントリーDOI: 10.2210/pdb4h5d/pdb
• 関連するPDBエントリー: 4DEM 4H5C 4H5E
• 分子名称: Farnesyl pyrophosphate synthase, [({4-[4-(propan-2-yloxy)phenyl]pyridin-2-yl}amino)methanediyl]bis(phosphonic acid), PYROPHOSPHATE 2-, ... (5 entities in total)
• 機能のキーワード: transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P14324
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43796.13

構造登録者

Park, J.,Lin, Y.-S.,Tsantrizos, Y.S.,Berghuis, A.M. (登録日: 2012-09-18, 公開日: 2012-12-26, 最終更新日: 2023-09-20)

• 主引用文献: Park, J.,Lin, Y.S.,De Schutter, J.W.,Tsantrizos, Y.S.,Berghuis, A.M.; Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme's active site closure.; Bmc Struct.Biol., 12:32-32, 2012; PubMed: 23234314; DOI: 10.1186/1472-6807-12-32

実験手法

X-RAY DIFFRACTION (2.02 Å)