4H5B

Crystal Structure of DR_1245 from Deinococcus radiodurans

4H5B の概要

• エントリーDOI: 10.2210/pdb4h5b/pdb
• 分子名称: DR_1245 protein, BROMIDE ION, GLYCEROL, ... (6 entities in total)
• 機能のキーワード: secretion chaperone-like fold, unknown function
• 由来する生物種: Deinococcus radiodurans
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 35820.84

構造登録者

Norais, C.,Servant, P.,Bouthier-de-la-Tour, C.,Coureux, P.D.,Ithurbide, S.,Vannier, F.,Guerin, P.,Dulberger, C.L.,Satyshur, K.A.,Keck, J.L.,Armengaud, J.,Cox, M.M.,Sommer, S. (登録日: 2012-09-18, 公開日: 2013-01-30, 最終更新日: 2024-02-28)

主引用文献

Norais, C.,Servant, P.,Bouthier-de-la-Tour, C.,Coureux, P.D.,Ithurbide, S.,Vannier, F.,Guerin, P.P.,Dulberger, C.L.,Satyshur, K.A.,Keck, J.L.,Armengaud, J.,Cox, M.M.,Sommer, S.
The Deinococcus radiodurans DR1245 Protein, a DdrB Partner Homologous to YbjN Proteins and Reminiscent of Type III Secretion System Chaperones.
Plos One, 8:e56558-e56558, 2013

PubMed Abstract: The bacterium Deinococcus radiodurans exhibits an extreme resistance to ionizing radiation. A small subset of Deinococcus genus-specific genes were shown to be up-regulated upon exposure to ionizing radiation and to play a role in genome reconstitution. These genes include an SSB-like protein called DdrB. Here, we identified a novel protein encoded by the dr1245 gene as an interacting partner of DdrB. A strain devoid of the DR1245 protein is impaired in growth, exhibiting a generation time approximately threefold that of the wild type strain while radioresistance is not affected. We determined the three-dimensional structure of DR1245, revealing a relationship with type III secretion system chaperones and YbjN family proteins. Thus, DR1245 may display some chaperone activity towards DdrB and possibly other substrates.

PubMed: 23441204
DOI: 10.1371/journal.pone.0056558

実験手法

X-RAY DIFFRACTION (2 Å)