4H53

Influenza N2-Tyr406Asp neuraminidase in complex with beta-Neu5Ac

4H53 の概要

• エントリーDOI: 10.2210/pdb4h53/pdb
• 関連するPDBエントリー: 4H52
• 分子名称: Neuraminidase, GLYCEROL, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• 機能のキーワード: neuraminidase, influenza virus surface, hydrolase
• 由来する生物種: Influenza A virus
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 180529.53

構造登録者

Vavricka, C.J.,Liu, Y.,Kiyota, H.,Sriwilaijaroen, N.,Qi, J.,Tanaka, K.,Wu, Y.,Li, Q.,Li, Y.,Yan, J.,Suzuki, Y.,Gao, G.F. (登録日: 2012-09-18, 公開日: 2013-02-20, 最終更新日: 2023-11-08)

• 主引用文献: Vavricka, C.J.,Liu, Y.,Kiyota, H.,Sriwilaijaroen, N.,Qi, J.,Tanaka, K.,Wu, Y.,Li, Q.,Li, Y.,Yan, J.,Suzuki, Y.,Gao, G.F.; Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors; Nat Commun, 4:1491-1491, 2013; PubMed: 23422659; DOI: 10.1038/ncomms2487

実験手法

X-RAY DIFFRACTION (1.5 Å)