4H52

Wild-type influenza N2 neuraminidase covalent complex with 3-fluoro-Neu5Ac

Summary for 4H52

• Entry DOI: 10.2210/pdb4h52/pdb
• Related: 4H53
• Descriptor: Neuraminidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: neuraminidase, influenza surface glycoprotein, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Influenza A virus
• Total number of polymer chains: 2
• Total formula weight: 89190.39

Authors

Vavricka, C.J.,Liu, Y.,Kiyota, H.,Sriwilaijaroen, N.,Qi, J.,Tanaka, K.,Wu, Y.,Li, Q.,Li, Y.,Yan, J.,Suzuki, Y.,Gao, G.F. (deposition date: 2012-09-18, release date: 2013-02-20, Last modification date: 2023-11-08)

• Primary citation: Vavricka, C.J.,Liu, Y.,Kiyota, H.,Sriwilaijaroen, N.,Qi, J.,Tanaka, K.,Wu, Y.,Li, Q.,Li, Y.,Yan, J.,Suzuki, Y.,Gao, G.F.; Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors; Nat Commun, 4:1491-1491, 2013; PubMed: 23422659; DOI: 10.1038/ncomms2487

Experimental method

X-RAY DIFFRACTION (1.803 Å)