4H3D

1.95 Angstrom Crystal Structure of of Type I 3-Dehydroquinate Dehydratase (aroD) from Clostridium difficile with Covalent Modified Comenic Acid.

4H3D の概要

• エントリーDOI: 10.2210/pdb4h3d/pdb
• 関連するPDBエントリー: 3JS3
• 分子名称: 3-dehydroquinate dehydratase, TRIETHYLENE GLYCOL, DI(HYDROXYETHYL)ETHER, ... (6 entities in total)
• 機能のキーワード: structural genomics, center for structural genomics of infectious diseases, csgid, tim barrel, aldolase class i, 3-dehydroquinate dehydratase activity, lyase
• 由来する生物種: Clostridium difficile
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 118122.42

構造登録者

Minasov, G.,Light, S.H.,Shuvalova, L.,Duban, M.-E.,Dubrovska, I.,Winsor, J.,Papazisi, L.,Anderson, W.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (登録日: 2012-09-13, 公開日: 2012-09-26, 最終更新日: 2026-02-18)

主引用文献

Rosas-Lemus, M.,Dey, S.,Minasov, G.,Tan, K.,Anderson, S.M.,Brunzelle, J.,Nocadello, S.,Shabalin, I.,Filippova, E.,Halavaty, A.,Kim, Y.,Maltseva, N.,Osipiuk, J.,Minor, W.,Joachimiak, A.,Savchenko, A.,Anderson, W.F.,Satchell, K.J.F.
A high-throughput structural system biology approach to increase structure representation of proteins from Clostridioides difficile.
Microbiol Resour Announc, 12:e0050723-e0050723, 2023

PubMed Abstract: causes life-threatening gastrointestinal infections. It is a high-risk pathogen due to a lack of effective treatments, antimicrobial resistance, and a poorly conserved genomic core. Herein, we report 30 X-ray structures from a structure genomics pipeline spanning 13 years, representing 10.2% of the X-ray structures for this important pathogen.

PubMed: 37747257
DOI: 10.1128/MRA.00507-23

実験手法

X-RAY DIFFRACTION (1.95 Å)