4H2O
Structure of E. coli undecaprenyl diphosphate synthase in complex with BPH-1248
Summary for 4H2O
Entry DOI | 10.2210/pdb4h2o/pdb |
Related | 4H2J 4H2M 4H38 4H3A 4H3C |
Descriptor | Undecaprenyl pyrophosphate synthase, 2-{[3-(decyloxy)benzoyl]amino}-5-nitrobenzoic acid (3 entities in total) |
Functional Keywords | prenyl transferase inhibitor complex, alpha-helix, prenyl transferase, cell wall biosynthesis, farnesyl diphosphate binding, isopentenyl diphosphate binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Escherichia coli |
Total number of polymer chains | 2 |
Total formula weight | 58289.77 |
Authors | Zhu, W.,Oldfield, E. (deposition date: 2012-09-13, release date: 2012-12-19, Last modification date: 2023-09-20) |
Primary citation | Zhu, W.,Zhang, Y.,Sinko, W.,Hensler, M.E.,Olson, J.,Molohon, K.J.,Lindert, S.,Cao, R.,Li, K.,Wang, K.,Wang, Y.,Liu, Y.L.,Sankovsky, A.,de Oliveira, C.A.,Mitchell, D.A.,Nizet, V.,McCammon, J.A.,Oldfield, E. Antibacterial drug leads targeting isoprenoid biosynthesis. Proc.Natl.Acad.Sci.USA, 110:123-128, 2013 Cited by PubMed: 23248302DOI: 10.1073/pnas.1219899110 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.14 Å) |
Structure validation
Download full validation report