4H2M

Structure of E. coli undecaprenyl diphosphate synthase in complex with BPH-1408

4H2M の概要

• エントリーDOI: 10.2210/pdb4h2m/pdb
• 関連するPDBエントリー: 4H2J 4H2O 4H38 4H3A 4H3C
• 分子名称: Undecaprenyl pyrophosphate synthase, 2,2'-{benzene-1,3-diylbis[ethyne-2,1-diyl(5-bromobenzene-3,1-diyl)]}diethanamine (3 entities in total)
• 機能のキーワード: prenyl transferase inhibitor complex, alpha-helix, prenyl transferase, cell wall biosynthesis, farnesyl diphosphate binding, isopentenyl diphosphate binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 58006.80

構造登録者

Zhu, W.,Oldfield, E. (登録日: 2012-09-12, 公開日: 2012-12-19, 最終更新日: 2023-09-20)

• 主引用文献: Zhu, W.,Zhang, Y.,Sinko, W.,Hensler, M.E.,Olson, J.,Molohon, K.J.,Lindert, S.,Cao, R.,Li, K.,Wang, K.,Wang, Y.,Liu, Y.L.,Sankovsky, A.,de Oliveira, C.A.,Mitchell, D.A.,Nizet, V.,McCammon, J.A.,Oldfield, E.; Antibacterial drug leads targeting isoprenoid biosynthesis.; Proc.Natl.Acad.Sci.USA, 110:123-128, 2013; PubMed: 23248302; DOI: 10.1073/pnas.1219899110

実験手法

X-RAY DIFFRACTION (1.78 Å)