4H1O
Crystal structure of the tyrosine phosphatase SHP-2 with D61G mutation
Summary for 4H1O
Entry DOI | 10.2210/pdb4h1o/pdb |
Related | 4GWF |
Descriptor | Tyrosine-protein phosphatase non-receptor type 11, 1,2-ETHANEDIOL (3 entities in total) |
Functional Keywords | alpha/beta proteins, sh2 domain, phosphatase domain, tyrosine phosphatase shp-2, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : Q06124 |
Total number of polymer chains | 1 |
Total formula weight | 64691.88 |
Authors | Qiu, W.,Lin, A.,Hutchinson, A.,Romanov, V.,Ruzanov, M.,Thompson, C.,Lam, K.,Kisselman, G.,Battaile, K.,Chirgadze, N.Y. (deposition date: 2012-09-11, release date: 2013-09-11, Last modification date: 2023-09-13) |
Primary citation | Qiu, W.,Lin, A.,Hutchinson, A.,Romanov, V.,Ruzanov, M.,Thompson, C.,Lam, K.,Kisselman, G.,Battaile, K.,Chirgadze, N.Y. Crystal structure of the tyrosine phosphatase SHP-2 with D61G mutation To be Published, |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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