4GWK
Crystal structure of 6-phosphogluconate dehydrogenase complexed with 3-phosphoglyceric acid
Summary for 4GWK
Entry DOI | 10.2210/pdb4gwk/pdb |
Related | 2JKV 4GWG |
Descriptor | 6-phosphogluconate dehydrogenase, decarboxylating, 3-PHOSPHOGLYCERIC ACID, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (4 entities in total) |
Functional Keywords | 6-phosphogluconate dehydrogenase, 3-phosphoglycerate, dehydrogenase, nadp, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm (By similarity): P52209 |
Total number of polymer chains | 1 |
Total formula weight | 54037.43 |
Authors | |
Primary citation | Hitosugi, T.,Zhou, L.,Elf, S.,Fan, J.,Kang, H.B.,Seo, J.H.,Shan, C.,Dai, Q.,Zhang, L.,Xie, J.,Gu, T.L.,Jin, P.,Aleckovic, M.,Leroy, G.,Kang, Y.,Sudderth, J.A.,Deberardinis, R.J.,Luan, C.H.,Chen, G.Z.,Muller, S.,Shin, D.M.,Owonikoko, T.K.,Lonial, S.,Arellano, M.L.,Khoury, H.J.,Khuri, F.R.,Lee, B.H.,Ye, K.,Boggon, T.J.,Kang, S.,He, C.,Chen, J. Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell, 22:585-600, 2012 Cited by PubMed: 23153533DOI: 10.1016/j.ccr.2012.09.020 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.534 Å) |
Structure validation
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