4GW8

Human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and Leucettine L41

4GW8 の概要

• エントリーDOI: 10.2210/pdb4gw8/pdb
• 分子名称: Serine/threonine-protein kinase pim-1, Consensus peptide (Pimtide), 5-(1,3-benzodioxol-5-ylmethyl)-2-(phenylamino)-4H-imidazol-4-one, ... (5 entities in total)
• 機能のキーワード: oncogene, kinase, serine-threonine, pim1, structural genomics consortium, sgc, alternative initiation, atp-binding, manganese, membrane, metal-binding, nucleotide-binding, nucleus, phosphoprotein, proto-oncogene, serine/threonine-protein kinase, transferase, host-virus interaction, viral immunoevasion, virion, virulence, cell cycle, cell membrane
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 37552.72

構造登録者

Filippakopoulos, P.,Bullock, A.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.,Meijer, L.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2012-09-01, 公開日: 2012-10-03, 最終更新日: 2023-09-13)

• 主引用文献: Tahtouh, T.,Elkins, J.M.,Filippakopoulos, P.,Soundararajan, M.,Burgy, G.,Durieu, E.,Cochet, C.,Schmid, R.S.,Lo, D.C.,Delhommel, F.,Oberholzer, A.E.,Pearl, L.H.,Carreaux, F.,Bazureau, J.P.,Knapp, S.,Meijer, L.; Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B.; J.Med.Chem., 55:9312-9330, 2012; PubMed: 22998443; DOI: 10.1021/jm301034u

実験手法

X-RAY DIFFRACTION (2 Å)