4GSF
The structure analysis of cysteine free insulin degrading enzyme (ide) with (s)-2-{2-[carboxymethyl-(3-phenyl-propionyl)-amino]-acetylamino}-3-(3h-imidazol-4-yl)-propionic acid methyl ester
Summary for 4GSF
Entry DOI | 10.2210/pdb4gsf/pdb |
Related | 4GS8 4GSC 4GSE |
Descriptor | Insulin-degrading enzyme, methyl N-(carboxymethyl)-N-(3-phenylpropanoyl)glycyl-D-histidinate, ZINC ION, ... (4 entities in total) |
Functional Keywords | insulin degrading enzyme, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P14735 |
Total number of polymer chains | 2 |
Total formula weight | 230084.83 |
Authors | Guo, Q.,Deprez-Poulain, R.,Deprez, B.,Tang, W.J. (deposition date: 2012-08-27, release date: 2013-08-28, Last modification date: 2023-09-13) |
Primary citation | Charton, J.,Gauriot, M.,Totobenazara, J.,Hennuyer, N.,Dumont, J.,Bosc, D.,Marechal, X.,Elbakali, J.,Herledan, A.,Wen, X.,Ronco, C.,Gras-Masse, H.,Heninot, A.,Pottiez, V.,Landry, V.,Staels, B.,Liang, W.G.,Leroux, F.,Tang, W.J.,Deprez, B.,Deprez-Poulain, R. Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme. Eur.J.Med.Chem., 90:547-567, 2015 Cited by PubMed: 25489670DOI: 10.1016/j.ejmech.2014.12.005 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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