4GS0
Crystal structure of SHP1 catalytic domain with JAK1 activation loop peptide
Summary for 4GS0
Entry DOI | 10.2210/pdb4gs0/pdb |
Descriptor | Tyrosine-protein phosphatase non-receptor type 6, Tyrosine-protein kinase JAK1 (3 entities in total) |
Functional Keywords | protein-protein complex, phosphatase domain, hydrolase, hydrolase-transferase complex, hydrolase/transferase |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: P29350 Endomembrane system; Peripheral membrane protein: P23458 |
Total number of polymer chains | 3 |
Total formula weight | 71324.26 |
Authors | Alicea-Velazquez, N.L.,Jakoncic, J.,Boggon, T.J. (deposition date: 2012-08-27, release date: 2012-12-19, Last modification date: 2023-09-13) |
Primary citation | Alicea-Velazquez, N.L.,Jakoncic, J.,Boggon, T.J. Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition. J.Struct.Biol., 181:243-251, 2013 Cited by PubMed: 23296072DOI: 10.1016/j.jsb.2012.12.009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7961 Å) |
Structure validation
Download full validation report