4GR1

THE BINDING OF THE RETRO-ANALOGUE OF GLUTATHIONE DISULFIDE TO GLUTATHIONE REDUCTASE

4GR1 の概要

• エントリーDOI: 10.2210/pdb4gr1/pdb
• 分子名称: GLUTATHIONE REDUCTASE, PHOSPHATE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (5 entities in total)
• 機能のキーワード: oxidoreductase (flavoenzyme)
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform Mitochondrial: Mitochondrion. Isoform Cytoplasmic: Cytoplasm: P00390
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 53129.39

構造登録者

Schulz, G.E.,Janes, W. (登録日: 1990-03-26, 公開日: 1991-10-15, 最終更新日: 2024-10-16)

主引用文献

Janes, W.,Schulz, G.E.
The binding of the retro-analogue of glutathione disulfide to glutathione reductase.
J.Biol.Chem., 265:10443-10445, 1990

PubMed Abstract: The retro-analogue of glutathione disulfide was bound to the GSSG binding site of crystalline glutathione reductase. The binding mode revealed why the analogue is a very poor substrate in enzyme catalysis. The observed binding mode difference between natural substrate and retro-analogue is explained.

PubMed: 2355009

実験手法

X-RAY DIFFRACTION (2.4 Å)