4GQQ
Human pancreatic alpha-amylase with bound ethyl caffeate
Summary for 4GQQ
Entry DOI | 10.2210/pdb4gqq/pdb |
Related | 1BSI 1CPU 1HNY 3IJ7 3IJ8 4GQR |
Descriptor | Pancreatic alpha-amylase, 2-acetamido-2-deoxy-beta-D-glucopyranose, ethyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate, ... (6 entities in total) |
Functional Keywords | glycosyl hydrolase, noncompetitive inhibition, diabetes, obesity, digestion, glycosidase, enzyme inhibition, flavonol, myricetin, drug design, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Secreted, extracellular space: P04746 |
Total number of polymer chains | 1 |
Total formula weight | 56852.68 |
Authors | Williams, L.K.,Brayer, G.D. (deposition date: 2012-08-23, release date: 2012-10-24, Last modification date: 2020-07-29) |
Primary citation | Williams, L.K.,Li, C.,Withers, S.G.,Brayer, G.D. Order and disorder: differential structural impacts of myricetin and ethyl caffeate on human amylase, an antidiabetic target. J.Med.Chem., 55:10177-10186, 2012 Cited by PubMed: 23050660DOI: 10.1021/jm301273u PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.35 Å) |
Structure validation
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