4GQQ

Human pancreatic alpha-amylase with bound ethyl caffeate

4GQQ の概要

• エントリーDOI: 10.2210/pdb4gqq/pdb
• 関連するPDBエントリー: 1BSI 1CPU 1HNY 3IJ7 3IJ8 4GQR
• 分子名称: Pancreatic alpha-amylase, 2-acetamido-2-deoxy-beta-D-glucopyranose, ethyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate, ... (6 entities in total)
• 機能のキーワード: glycosyl hydrolase, noncompetitive inhibition, diabetes, obesity, digestion, glycosidase, enzyme inhibition, flavonol, myricetin, drug design, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted, extracellular space: P04746
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 56852.68

構造登録者

Williams, L.K.,Brayer, G.D. (登録日: 2012-08-23, 公開日: 2012-10-24, 最終更新日: 2020-07-29)

• 主引用文献: Williams, L.K.,Li, C.,Withers, S.G.,Brayer, G.D.; Order and disorder: differential structural impacts of myricetin and ethyl caffeate on human amylase, an antidiabetic target.; J.Med.Chem., 55:10177-10186, 2012; PubMed: 23050660; DOI: 10.1021/jm301273u

実験手法

X-RAY DIFFRACTION (1.35 Å)