4GQG

Crystal structure of AKR1B10 complexed with NADP+

4GQG の概要

• エントリーDOI: 10.2210/pdb4gqg/pdb
• 分子名称: Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (3 entities in total)
• 機能のキーワード: alpha-beta tim barrel, nadp-dependant oxidoreductase, nadp+, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Lysosome: O60218
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37041.16

構造登録者

Zhang, L.,Zheng, X.,Chen, S.,Zhai, J.,Hu, X. (登録日: 2012-08-23, 公開日: 2013-08-28, 最終更新日: 2023-11-08)

• 主引用文献: Zhang, L.,Zhang, H.,Zhao, Y.,Li, Z.,Chen, S.,Zhai, J.,Chen, Y.,Xie, W.,Wang, Z.,Li, Q.,Zheng, X.,Hu, X.; Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: Role of Trp112 (Trp111); Febs Lett., 587:3681-3686, 2013; PubMed: 24100137; DOI: 10.1016/j.febslet.2013.09.031

実験手法

X-RAY DIFFRACTION (1.92 Å)