4GQ4
Human menin with bound inhibitor MI-2-2
Summary for 4GQ4
Entry DOI | 10.2210/pdb4gq4/pdb |
Related | 4GPQ 4GQ3 4GQ6 |
Descriptor | Menin, 4-[4-(5,5-dimethyl-4,5-dihydro-1,3-thiazol-2-yl)piperazin-1-yl]-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidine, UNKNOWN ATOM OR ION, ... (8 entities in total) |
Functional Keywords | tumor suppressor, nucleus, transcription-transcription inhibitor complex, transcription/transcription inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: O00255 |
Total number of polymer chains | 1 |
Total formula weight | 56395.28 |
Authors | Shi, A.,Murai, M.J.,He, S.,Lund, G.L.,Hartley, T.,Purohit, T.,Reddy, G.,Chruszcz, M.,Grembecka, J.,Cierpicki, T. (deposition date: 2012-08-22, release date: 2012-09-19, Last modification date: 2024-02-28) |
Primary citation | Shi, A.,Murai, M.J.,He, S.,Lund, G.,Hartley, T.,Purohit, T.,Reddy, G.,Chruszcz, M.,Grembecka, J.,Cierpicki, T. Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia. Blood, 120:4461-4469, 2012 Cited by PubMed: 22936661DOI: 10.1182/blood-2012-05-429274 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.27 Å) |
Structure validation
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