4GPW

Crystal structure of the protozoal cytoplasmic ribosomal decoding site in complex with 6'-hydroxysisomicin (P21212 form)

4GPW の概要

• エントリーDOI: 10.2210/pdb4gpw/pdb
• 関連するPDBエントリー: 2F8U 2F8V 4GPX 4GPY
• 分子名称: RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3'), (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(hydroxymethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside (3 entities in total)
• 機能のキーワード: ribosome, aminoglycoside, rna-antibiotic complex, antiprotozoal activity, antibacterial activity, rna/antibiotic
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 15669.87

構造登録者

Kondo, J.,Koganei, M.,Maianti, J.P.,Ly, V.L.,Hanessian, S. (登録日: 2012-08-22, 公開日: 2013-04-03, 最終更新日: 2024-03-20)

• 主引用文献: Kondo, J.,Koganei, M.,Maianti, J.P.,Ly, V.L.,Hanessian, S.; Crystal structures of a bioactive 6'-hydroxy variant of sisomicin bound to the bacterial and protozoal ribosomal decoding sites; Chemmedchem, 8:733-739, 2013; PubMed: 23436717; DOI: 10.1002/cmdc.201200579

実験手法

X-RAY DIFFRACTION (3 Å)