4GLX

DNA ligase A in complex with inhibitor

Summary for 4GLX

• Entry DOI: 10.2210/pdb4glx/pdb
• Related: 3baa 4GLW
• Descriptor: DNA (26-MER), DNA (5'-D(*AP*CP*AP*AP*TP*TP*GP*CP*GP*AP*CP*CP*C)-3'), DNA (5'-D(P*CP*AP*CP*TP*AP*TP*CP*GP*GP*AP*AP*TP*G)-3'), ... (8 entities in total)
• Functional Keywords: dna ligase a, inhibitor, ligase-ligase inhibitor-dna complex, ligase/ligase inhibitor/dna
• Biological source: Escherichia coli; More
• Total number of polymer chains: 4
• Total formula weight: 81352.74

Authors

Prade, L.,Lange, R.,Tidten-Luksch, N.,Chambovey, A. (deposition date: 2012-08-15, release date: 2012-10-10, Last modification date: 2024-02-28)

• Primary citation: Surivet, J.P.,Lange, R.,Hubschwerlen, C.,Keck, W.,Specklin, J.L.,Ritz, D.,Bur, D.,Locher, H.,Seiler, P.,Strasser, D.S.,Prade, L.,Kohl, C.,Schmitt, C.,Chapoux, G.,Ilhan, E.,Ekambaram, N.,Athanasiou, A.,Knezevic, A.,Sabato, D.,Chambovey, A.,Gaertner, M.,Enderlin, M.,Boehme, M.,Sippel, V.,Wyss, P.; Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity.; Bioorg.Med.Chem.Lett., 22:6705-6711, 2012; PubMed: 23006603; DOI: 10.1016/j.bmcl.2012.08.094

Experimental method

X-RAY DIFFRACTION (1.9 Å)