4GL2
Structural Basis for dsRNA duplex backbone recognition by MDA5
Summary for 4GL2
Entry DOI | 10.2210/pdb4gl2/pdb |
Descriptor | Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(*AP*UP*CP*CP*GP*CP*GP*GP*CP*CP*CP*U)-3'), RNA (5'-R(P*AP*GP*GP*GP*CP*CP*GP*CP*GP*GP*AP*U)-3'), ... (5 entities in total) |
Functional Keywords | mda5, dsrna, anti-viral signaling, rig-i, mavs, oligomerization, helicase, atpase, filament formation, rna binding protein-rna complex, rna binding protein/rna |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q9BYX4 |
Total number of polymer chains | 6 |
Total formula weight | 177417.52 |
Authors | |
Primary citation | Wu, B.,Peisley, A.,Richards, C.,Yao, H.,Zeng, X.,Lin, C.,Chu, F.,Walz, T.,Hur, S. Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5. Cell(Cambridge,Mass.), 152:276-289, 2013 Cited by PubMed: 23273991DOI: 10.1016/j.cell.2012.11.048 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.557 Å) |
Structure validation
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