4GL2

Structural Basis for dsRNA duplex backbone recognition by MDA5

4GL2 の概要

• エントリーDOI: 10.2210/pdb4gl2/pdb
• 分子名称: Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(*AP*UP*CP*CP*GP*CP*GP*GP*CP*CP*CP*U)-3'), RNA (5'-R(P*AP*GP*GP*GP*CP*CP*GP*CP*GP*GP*AP*U)-3'), ... (5 entities in total)
• 機能のキーワード: mda5, dsrna, anti-viral signaling, rig-i, mavs, oligomerization, helicase, atpase, filament formation, rna binding protein-rna complex, rna binding protein/rna
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: Q9BYX4
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 177417.52

構造登録者

Wu, B.,Hur, S. (登録日: 2012-08-13, 公開日: 2013-01-09, 最終更新日: 2013-02-06)

• 主引用文献: Wu, B.,Peisley, A.,Richards, C.,Yao, H.,Zeng, X.,Lin, C.,Chu, F.,Walz, T.,Hur, S.; Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5.; Cell(Cambridge,Mass.), 152:276-289, 2013; PubMed: 23273991; DOI: 10.1016/j.cell.2012.11.048

実験手法

X-RAY DIFFRACTION (3.557 Å)