4GK7

yeast 20S proteasome in complex with the Syringolin-Glidobactin chimera

4GK7 の概要

• エントリーDOI: 10.2210/pdb4gk7/pdb
• 関連するPDBエントリー: 1RYP 2ZCY 3BDM
• 関連するBIRD辞書のPRD_ID: PRD_001047
• 分子名称: Proteasome component Y7, Proteasome component C11, Proteasome component PRE2, ... (16 entities in total)
• 機能のキーワード: proteasome, cancer, protein degradation, inhibition, natural product derivative, ntn-hydrolase, hydrolase-hydrolase inhibitor complex, 12-membered dipeptide-macrolactam, hydrolase/hydrolase inhibitor
• 由来する生物種: Saccharomyces cerevisiae (Baker's yeast); 詳細
• 細胞内の位置: Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
• タンパク質・核酸の鎖数: 34
• 化学式量合計: 707510.63

構造登録者

Groll, M.,Stein, M.L.,Bachmann, A. (登録日: 2012-08-10, 公開日: 2012-08-29, 最終更新日: 2023-11-15)

• 主引用文献: Archer, C.R.,Groll, M.,Stein, M.L.,Schellenberg, B.,Clerc, J.,Kaiser, M.,Kondratyuk, T.P.,Pezzuto, J.M.,Dudler, R.,Bachmann, A.S.; Activity enhancement of the synthetic syrbactin proteasome inhibitor hybrid and biological evaluation in tumor cells.; Biochemistry, 51:6880-6888, 2012; PubMed: 22870914; DOI: 10.1021/bi300841r

実験手法

X-RAY DIFFRACTION (2.8 Å)