4PVS

Crystal structure of fully-cleaved human l-asparaginase protein in complex with l-aspartate

Replaces:  4GDW

Summary for 4PVS

• Entry DOI: 10.2210/pdb4pvs/pdb
• Related: 4PVP 4PVQ 4PVR
• Descriptor: Isoaspartyl peptidase/L-asparaginase, SODIUM ION, ASPARTIC ACID, ... (4 entities in total)
• Functional Keywords: ntn enzyme, homodimer, hydrolase, l-asparagine
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q7L266
• Total number of polymer chains: 2
• Total formula weight: 64891.56

Authors

Nomme, J.,Lavie, A. (deposition date: 2014-03-18, release date: 2014-03-26, Last modification date: 2024-02-28)

• Primary citation: Nomme, J.,Su, Y.,Konrad, M.,Lavie, A.; Structures of apo and product-bound human L-asparaginase: insights into the mechanism of autoproteolysis and substrate hydrolysis.; Biochemistry, 51:6816-6826, 2012; PubMed: 22861376; DOI: 10.1021/bi300870g

Experimental method

X-RAY DIFFRACTION (1.84 Å)