4GDB

SHV-1 in complex with 4H-pyrazolo[1,5-c][1,3]thiazole containing penem inhibitor

Summary for 4GDB

Entry DOI	10.2210/pdb4gdb/pdb
Related	1Q2P 4GD6 4GD8
Descriptor	Beta-lactamase SHV-1, (7R)-6-formyl-7-(4H-pyrazolo[1,5-c][1,3]thiazol-2-yl)-4,7-dihydro-1,4-thiazepine-3-carboxylic acid, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, ... (5 entities in total)
Functional Keywords	class a beta-lactamase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Klebsiella pneumoniae
Total number of polymer chains	1
Total formula weight	32824.86
Authors	Ke, W.,van den Akker, F. (deposition date: 2012-07-31, release date: 2013-07-31, Last modification date: 2017-11-15)
Primary citation	Ke, W.,Pattanaik, P.,Bethel, C.R.,Sheri, A.,Buynak, J.D.,Bonomo, R.A.,van den Akker, F. Structures of SHV-1 beta-lactamase with penem and penam sulfone inhibitors that form cyclic intermediates stabilized by carbonyl conjugation Plos One, 7:e49035-e49035, 2012 Cited by PubMed: 23145056 DOI: 10.1371/journal.pone.0049035 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.84 Å)

Structure validation