4G8Z

pcDHFR K37S/F69N double mutant TMP NADPH ternary complex

4G8Z の概要

• エントリーDOI: 10.2210/pdb4g8z/pdb
• 関連するPDBエントリー: 1dyr
• 分子名称: Dihydrofolate reductase, TRIMETHOPRIM, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
• 機能のキーワード: mutant pcdhfr inhibitor complex, tmp/nadph ligands, k37s and f69n mutations, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Pneumocystis jirovecii
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24416.62

構造登録者

Cody, V. (登録日: 2012-07-23, 公開日: 2013-05-29, 最終更新日: 2023-09-13)

• 主引用文献: Cody, V.,Pace, J.,Queener, S.F.,Adair, O.O.,Gangjee, A.; Kinetic and Structural Analysis for Potent Antifolate Inhibition of Pneumocystis jirovecii, Pneumocystis carinii, and Human Dihydrofolate Reductases and Their Active-Site Variants.; Antimicrob.Agents Chemother., 57:2669-2677, 2013; PubMed: 23545530; DOI: 10.1128/AAC.00172-13

実験手法

X-RAY DIFFRACTION (1.75 Å)