4G8A

Crystal structure of human TLR4 polymorphic variant D299G and T399I in complex with MD-2 and LPS

Summary for 4G8A

Entry DOI	10.2210/pdb4g8a/pdb
Descriptor	Toll-like receptor 4, Lymphocyte antigen 96, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
Functional Keywords	leucine rich repeat md-2 related lipid recognition, receptor, innate immunity, lipid binding, glycosylation, immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	184511.91
Authors	Ohto, U.,Shimizu, T. (deposition date: 2012-07-23, release date: 2012-10-17, Last modification date: 2023-11-08)
Primary citation	Ohto, U.,Yamakawa, N.,Akashi-Takamura, S.,Miyake, K.,Shimizu, T. Structural analyses of human Toll-like receptor 4 polymorphisms D299G and T399I J.Biol.Chem., 287:40611-40617, 2012 Cited by PubMed Abstract: TLR4 polymorphism replacing Asp-299 with Gly and Thr-399 with Ile (D299G/T399I) causes LPS hyporesponsiveness. PubMed: 23055527 DOI: 10.1074/jbc.M112.404608 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation