4G6A

Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody AP33

4G6A の概要

• エントリーDOI: 10.2210/pdb4g6a/pdb
• 分子名称: E2 peptide, AP33 Heavy Chain, AP33 Light chain, ... (4 entities in total)
• 機能のキーワード: immunoglobulin fold, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 98739.66

構造登録者

Kong, L.,Wilson, I.A.,Law, M. (登録日: 2012-07-18, 公開日: 2012-09-26, 最終更新日: 2024-10-30)

主引用文献

Kong, L.,Giang, E.,Nieusma, T.,Robbins, J.B.,Deller, M.C.,Stanfield, R.L.,Wilson, I.A.,Law, M.
Structure of Hepatitis C Virus Envelope Glycoprotein E2 Antigenic Site 412 to 423 in Complex with Antibody AP33.
J.Virol., 86:13085-13088, 2012

PubMed Abstract: We have determined the crystal structure of the broadly neutralizing antibody (bnAb) AP33, bound to a peptide corresponding to hepatitis C virus (HCV) E2 envelope glycoprotein antigenic site 412 to 423. Comparison with bnAb HCV1 bound to the same epitope reveals a different angle of approach to the antigen by bnAb AP33 and slight variation in its β-hairpin conformation of the epitope. These structures establish two different modes of binding to E2 that antibodies adopt to neutralize diverse HCV.

PubMed: 22973046
DOI: 10.1128/JVI.01939-12

実験手法

X-RAY DIFFRACTION (2.501 Å)