4G3T

Mycobacterium smegmatis DprE1 - hexagonal crystal form

Summary for 4G3T

• Entry DOI: 10.2210/pdb4g3t/pdb
• Related: 4G3U
• Descriptor: oxidoreductase DprE1 (2 entities in total)
• Functional Keywords: vao superfamily, oxidoreductase
• Biological source: Mycobacterium smegmatis
• Total number of polymer chains: 1
• Total formula weight: 44441.18

Authors

Li, H.,Jogl, G. (deposition date: 2012-07-15, release date: 2012-12-05, Last modification date: 2024-02-28)

Primary citation

Li, H.,Jogl, G.
Crystal structure of decaprenylphosphoryl-beta- D-ribose 2'-epimerase from Mycobacterium smegmatis.
Proteins, 81:538-543, 2013

PubMed Abstract: Decaprenylphosphoryl-β-D-ribose 2'-epimerase (DprE1) is an essential enzyme in the biosynthesis of cell wall components and a target for development of anti-tuberculosis drugs. We determined the crystal structure of a truncated form of DprE1 from Mycobacterium smegmatis in two crystal forms to up to 2.35 Å resolution. The structure extends from residue 75 to the C-terminus and shares homology with FAD-dependent oxidoreductases of the vanillyl-alcohol oxidase family including the DprE1 homologue from M. tuberculosis. The M. smegmatis DprE1 structure reported here provides further insights into the active site geometry of this tuberculosis drug target.

PubMed: 23184707
DOI: 10.1002/prot.24220

Experimental method

X-RAY DIFFRACTION (2.346 Å)