4G2W

Crystal structure of PDE5A in complex with its inhibitor

Summary for 4G2W

Entry DOI	10.2210/pdb4g2w/pdb
Related	4G2Y
Descriptor	cGMP-specific 3',5'-cyclic phosphodiesterase, 5,6-diethyl-2-{5-[(4-methylpiperazin-1-yl)sulfonyl]-2-propoxyphenyl}pyrimidin-4(3H)-one, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	phosphodiesterase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	40735.50
Authors	Ren, J.,Chen, T.T.,Xu, Y.C. (deposition date: 2012-07-13, release date: 2013-06-26, Last modification date: 2023-11-08)
Primary citation	Wang, G.,Liu, Z.,Chen, T.T.,Wang, Z.,Yang, H.,Zheng, M.,Ren, J.,Tian, G.,Yang, X.,Li, L.,Li, J.,Suo, J.,Zhang, R.,Jiang, X.,Terrett, N.K.,Shen, J.,Xu, Y.C.,Jiang, H. Design, synthesis, and pharmacological evaluation of monocyclic pyrimidinones as novel inhibitors of PDE5. J.Med.Chem., 55:10540-10550, 2012 Cited by PubMed: 23137303 DOI: 10.1021/jm301159y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.28 Å)

Structure validation