4G2W

Crystal structure of PDE5A in complex with its inhibitor

4G2W の概要

• エントリーDOI: 10.2210/pdb4g2w/pdb
• 関連するPDBエントリー: 4G2Y
• 分子名称: cGMP-specific 3',5'-cyclic phosphodiesterase, 5,6-diethyl-2-{5-[(4-methylpiperazin-1-yl)sulfonyl]-2-propoxyphenyl}pyrimidin-4(3H)-one, MAGNESIUM ION, ... (6 entities in total)
• 機能のキーワード: phosphodiesterase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40735.50

構造登録者

Ren, J.,Chen, T.T.,Xu, Y.C. (登録日: 2012-07-13, 公開日: 2013-06-26, 最終更新日: 2023-11-08)

• 主引用文献: Wang, G.,Liu, Z.,Chen, T.T.,Wang, Z.,Yang, H.,Zheng, M.,Ren, J.,Tian, G.,Yang, X.,Li, L.,Li, J.,Suo, J.,Zhang, R.,Jiang, X.,Terrett, N.K.,Shen, J.,Xu, Y.C.,Jiang, H.; Design, synthesis, and pharmacological evaluation of monocyclic pyrimidinones as novel inhibitors of PDE5.; J.Med.Chem., 55:10540-10550, 2012; PubMed: 23137303; DOI: 10.1021/jm301159y

実験手法

X-RAY DIFFRACTION (2.28 Å)