4G2H
Structural basis for the accommodation of bis- and tris-aromatic derivatives in Vitamin D Nuclear Receptor
Summary for 4G2H
Entry DOI | 10.2210/pdb4g2h/pdb |
Related | 4G1D 4G1Y 4G1Z 4G20 4G21 4G2I |
Descriptor | Vitamin D3 receptor A, Nuclear receptor coactivator 1, (3E,5E)-6-(3-{2-[3,4-bis(hydroxymethyl)phenyl]ethyl}phenyl)-1,1,1-trifluoro-2-(trifluoromethyl)octa-3,5-dien-2-ol, ... (4 entities in total) |
Functional Keywords | vdr, transcription regulation, nuclear receptor, alpha helical sandwich, trasncription regulation, ligand, dna, phosphorylation, nucleus, transcription-transcription inhibitor complex, transcription/transcription inhibitor |
Biological source | Danio rerio (leopard danio,zebra danio,zebra fish) More |
Cellular location | Nucleus: Q9PTN2 Nucleus (By similarity): Q15788 |
Total number of polymer chains | 2 |
Total formula weight | 36181.08 |
Authors | Ciesielski, F.,Sato, Y.,Moras, D.,Rochel, N. (deposition date: 2012-07-12, release date: 2012-09-26, Last modification date: 2024-02-28) |
Primary citation | Ciesielski, F.,Sato, Y.,Chebaro, Y.,Moras, D.,Dejaegere, A.,Rochel, N. Structural basis for the accommodation of bis- and tris-aromatic derivatives in vitamin d nuclear receptor. J.Med.Chem., 55:8440-8449, 2012 Cited by PubMed: 22957834DOI: 10.1021/jm300858s PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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